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Early Detection of Lung Cancer: A Role for Serum Biomarkers?

I.Broodman

Lung cancer has the highest mortality rate among cancer patients in the world, in particular because most patients are only diagnosed at an advanced and non-curable stage. Computed tomography (CT) screening on high-risk individuals has shown that early detection could reduce the mortality rate. However, the still high false-positive rate of CT may harm healthy individuals because of unnecessary follow-up scans and invasive follow-up procedures. On the other hand, false-negative and indeterminate results may harm patients due to the delayed diagnosis and treatment of lung cancer. Non-invasive biomarkers, complementary to CT screening, could lower the false-positive and false-negative rate of CT screening at baseline screening. The aim of this thesis was to identify lung cancer-associated proteins, especially sequences of autoantibodies, as potential non-invasive biomarkers for early detection of lung cancer. We applied immunological and high-performance proteomics techniques to identify and quantify these proteins in serum of high-risk individuals from a well-controlled multicenter population study (NELSON).


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