Publish digitally?

Reading ePubs made easy with the Optima Reader. Click and Read!

+3110 220 11 49 account@ogc.nl
Sort by:
Category:

Title

Author

No summary.

<>

The role of the blood-brain barrier in drug resistance and central neurotoxicity

F. Froklage

Efflux transporters at the blood-brain barrier, such as P-glycoprotein (P-gp), transport potential toxic substances from the brain to the blood and thereby serve to protect the brain. However dysfunctioning of these efflux transporters may occur. In the case of P-gp upregulation, this may lead to pharmacoresistance. In contrast, decreased P-gp functioning may lead to central neurotoxicity. A first step towards understanding more about these mechanisms was to ‘image’ P-gp. Femke Froklage and colleagues decided to tackle this challenge. Will P-gp let itself be imaged? What were the obstacles? And did they succeed in what they were aiming at? By reading this book you can follow their scientific journey.


Optima Reader

PDF

This publication requires a passcode.

Unlock